Human papillomavirus (HPV) affects epithelial cells and has a particle diameter of 55 nm. A special feature is the proliferation of the skin epithelium as well as mucous membranes. In the initial phase, the pathogen usually affects the basal cells of the epithelium, penetrating them through microtraumas. Localized papillomas are usually found on the skin of the neck, armpits, groin and genitals (most often), oral mucosa and nasopharynx.
This virus can exist for many years without symptoms. To detect HPV, electron microscopy or molecular hybridization methods are used.
Types of human papillomavirus
In humans, there is HPV, which affects the mucous membranes and skin. Among the large number of papillomaviruses, species with low and high oncogenic risk are distinguished. It has been proven that oncogenic properties are associated with the ability to integrate DNA into the genome of human cells.
The virus is activated in 10-20% of cases. Depending on the type, it can cause benign or malignant lesions. Some HPVs are not oncogenic. They lead to the appearance of warts and genital warts. The most common are HPV 6 and 11.
HPV oncogenes are those that present a high risk of developing cancerous lesions, especially in the cervix or anus. In the skin, HPV 16 and 18, as well as HPV 5 and 8, which can lead to skin cancer, are more common. The best-known form of cancer caused by HPV is cervical cancer. But men can also be infected by the papilloma virus, which, in the worst cases, causes cancer of the penis or anus.
Often, women encounter HPV 16 - this is a form in which introsomal parasitism is observed, that is, outside the cell chromosome (benign). HPV 18 presents a high risk of developing cancer - benign tumors are first formed, which after some time degenerate into cancer. Virions in this case have tiny sizes (up to 30 nm).
- cervical neoplasms;
- invasive or pre-invasive oncology;
- urinary tract and genital warts.
Features of the infection
The human papillomavirus is highly contagious. It is usually transmitted by direct contact, skin-to-skin or mucosa-to-mucosa, with an infected person. For a genital infection, this most often occurs during vaginal or oral intercourse. Having a large number of sexual partners or other STIs (sexually transmitted infections) increases your risk. Indirect transmission through contaminated objects, clothing or bedding is also possible, but is quite rare.
In 7% of cases, transmission of the virus from mother to child can occur during childbirth, when the infection is active. The risk increases to 40% if infected with HPV 16 or 18.
Penetrating into the epithelium, violating its integrity, papillomavirus infection promotes the growth of the lower layer of epithelial cells in the form of condylomas or warts. This form of the disease is contagious and spreads quickly to other people. As a rule, warts and condylomas do not metastasize and often disappear spontaneously.
HPV symptoms
The incubation period lasts up to 9 months (average 3 months). HPV can be present in the body without obvious symptoms. The virus can go unnoticed for months or years. Even at this stage it is contagious.
Skin warts usually occur in groups and increase in number when scratched. The two most common forms of papillomas are grayish, hard, raised and with a broken surface (common wart) or flat and reddish (flat wart). Spiny warts occur on the soles of the feet or heels, grow inwards and are therefore often painful.
- Genital warts. Pale or reddish nodules that usually appear in groups and occur on the labia, vagina, penis, urethra, anal canal, and rectum. They are highly contagious.
- Flat condylomas. They appear in the form of flat nodules and are mainly found on the female genitals. They increase the risk of developing cancer.
- Giant condylomas (Buschke-Levenshtein tumors). They grow into huge formations, destroying the surrounding tissues. In rare cases, they can degenerate and cause squamous cell carcinoma.
Infection of the mucous membranes of the upper respiratory tract is also possible. The conjunctiva of the eyes may be affected, resulting in pink growths.
It is more difficult to detect an asymptomatic course, which the doctor can only see with the help of auxiliary means such as acetic acid (causes discoloration of the warts) or a microscope.
Furthermore, the virus can also take up residence in cells without any changes to the tissues. There they talk about latent infection, that is, the presence of pathogens, but without symptoms. Once infected, this phase can last from several weeks to several months.
Possible consequences
When infected, the viruses penetrate the cells of the integumentary tissue of the skin and mucous membranes, settle in the nuclei of cellular structures and multiply there. Typically, these HPV infections go unnoticed and heal on their own without consequences, as the immune system successfully fights the pathogen.
However, some types of HPV create changes in the skin called growths. Possible forms include genital warts or condylomas and papillomas, which can affect, for example, the face, arms or legs.
The tissue changes caused are mostly benign, but they can also degenerate and lead to cancer. For example, cancer can occur decades after an HPV infection. Cancer of the female external genitalia (cancer of the vulva and vagina), anal cancer, penile cancer, and cancer of the mouth and throat (head and neck tumors) are also possible.
Establishing diagnosis
A test for HPV infection is performed on women as part of preventive visits to the gynecologist. During a gynecological exam, a swab of the lining of the cervix is taken, called a Pap test (cytological test). The resulting material is studied for tissue changes to determine precancerous conditions.
Additionally, an HPV test may be performed, in which cellular material from a mucosal swab or tissue sample is tested in the laboratory for the presence of certain viruses. However, this only proves that the affected area is infected, but does not make any statements about whether tissue changes have occurred. So an HPV test makes sense, especially when combined with a Pap test, and can help detect cancer precursors at an early stage.
If the test is positive, there is no reason to worry as infections do not always lead to cancer. Regular examination is recommended to detect tissue changes at an early stage. On the other hand, a negative test result does not indicate whether there was a previous infection that the body successfully fought off.
For men, there is no preventive exam in which the test is performed regularly. If there is an underlying cancer, testing the tumor can determine whether HPV infection is underlying the cancer.
Specialized DNA methods are also used in laboratory diagnostics, such as real-time PCR. Anogenital warts caused by HPV types 6 and 11 are easily detected during a gynecological exam.
How to cure human papillomavirus
In most cases, the disease does not require treatment because it disappears on its own and then the viruses are no longer detected. However, if this is not the case, the infection may last longer and persist for months or years.
To date, there are no methods of systemic influence on this virus that could completely destroy it. However, treating existing warts reduces the number of viruses, so in many cases the immune system can combat the remaining viruses and thus get rid of them. In some cases, pathogens survive and can cause disease symptoms repeatedly.
- Plantar and genital warts can be treated with medications formulated with salicylic acid for topical application.
- Cryotherapy is also a frequently used method for HPV. In this case, the wart is burned with cold, using liquid nitrogen.
- Lasers or electrocauterization are also used methods.
For cancer caused by HPV, treatment is much more difficult. For cervical cancer, it is often advisable to remove the uterus, respectively the upper part of the vagina and the ovaries. This can be supplemented with radiotherapy to eliminate the possibility of relapse. Other types of cancer caused by HPV are more often treated with targeted therapy, such as radiation or chemotherapy.
It must be remembered that the operation is not a radical solution, but only solves a cosmetic problem, since after removal the virus may remain in the surrounding tissues and condylomas may reappear.
Infection prevention
There are two vaccines: a bivalent vaccine against HPV 16 and 18 and a quadrivalent vaccine against HPV 6, 11, 16 and 18. Vaccination is recommended for all girls aged 14 and over.
Vaccination does not protect against all types of HPV. Therefore, all women aged 25 to 65, even if vaccinated, are advised to undergo periodic smear tests.
Timely detection and complete removal of condylomas reduces the risk of disease. The effectiveness of using condoms to protect against the transmission of infection can significantly reduce the risk of developing this disease. The most promising way to prevent and treat the early stages of the disease caused by this infection is a specific multipurpose vaccine.
Why do plantar warts appear and treatment methods
Warts are skin lesions that appear in the form of special round formations that protrude above the surface. They arise due to specific viruses.
These formations often cause physical discomfort due to their location. Even after treatment, they tend to recur.
Types and reasons
There are many varieties of warts; They are classified according to a series of characteristics:
- Simple. They occur on exposed parts of the body, arms, legs, face and scalp. They are generally not dangerous, but they are not aesthetically pleasing and can multiply quickly, affecting large areas of the skin. They are organized as if they were "families".
- To plant. Its location is exclusively on the feet. It causes discomfort when walking.
The main cause is infection with the human papillomavirus, which affects the mucous membranes and skin.
Human papillomavirus
This is one of the most common viruses on Earth. Infection can occur in several ways:
- contact and domicile (through touch);
- sexual (genital, anal, oral-genital);
- in childbirth from mother to child.
The period of development of the disease varies from several weeks to tens of years, this is explained by the fact that the virus may not manifest itself for a long time, but as soon as immunity becomes a little weaker, growths immediately appear on the skin and/ or mucous membranes. The main danger of this disease is that certain types of HPV are very likely to cause the formation of a malignant tumor (cancer of the skin or mucous membranes). To be sure that the disease will not lead to the formation of a tumor, it is necessary to undergo a medical examination and not self-medicate.
Symptoms and types of warts on the feet
A plantar wart appears as a callus-like thickening with a layer of stratum corneum skin. It interferes with walking and causes pain. The passive state is characterized by slow reproduction, not reaching the stratum corneum of the epithelium, therefore this condition does not manifest itself externally.
The active state is characterized by the fact that the virus develops rapidly and, rising to the upper layers of the epidermis, manifests itself through numerous symptoms. Plantar wart is also called spiny wart, chicken wart. The virus enters during skin contact through cuts and abrasions in the outer layer of the skin:
- First, a small yellowish-gray papule with an uneven surface appears.
- Gradually, the small element becomes dense and acquires a dirty color.
From the inside, a plantar wart looks like fused papillae of different sizes with a pinkish tint. Additional capillaries form there, causing bleeding if you get a wart.
Plantar wart removal
It is worth treating a plantar wart if:
- There are painful sensations.
- The wart is bleeding.
- There were stains on it.
- The wart quickly increases in size.
There are many treatment methods. One of them is cryodestruction. The meaning of the method is that the wart is exposed to liquid nitrogen at a temperature of minus 196 degrees. The area affected by the virus is frozen and the wart is removed.
The usual and aggressive method of exposure is used. With the aggressive method, nitrogen is applied for a few more seconds, but this method is more painful. It is important to note that if a wart appears and exists for more than six months, the effectiveness of cryodestruction will be greatly reduced and the meaning of such an operation, accordingly, will also disappear.
After removing a plantar wart with liquid nitrogen, you must follow some recommendations:
- the blister remaining at the site of the wart cannot be opened;
- to avoid mechanical damage, use a sterile bandage instead of a plaster;
- Treat the affected area with 2% salicylic alcohol twice a day;
- try to prevent water from entering the affected area.
Another method is laser coagulation. This is one of the most common methods for removing warts. Most laser systems are equipped with a special cooling system. Thus, the procedure takes place with minimal discomfort and does not allow inflammation, as the laser has antiseptic properties. Furthermore, this is a contactless method.
There are several ways:
- Carbon dioxide (CO2) laser. Treatment in this case takes place with infrared light. The method is 70% effective, but the downside is that healthy tissue can also be damaged.
- Erbium laser. This treatment method uses a shorter wavelength, which reduces the likelihood of scarring after surgery. Efficiency is typically 75%.
- Pulsed dye laser. With this method of exposure, primary destruction of dilated capillaries in the wart and stimulation of the immune system occurs, which contributes to effective healing. The effectiveness of the treatment is around 95%.
After laser treatment, a scab forms on the affected area, which disappears on its own within seven to ten days. Recommendations for this treatment method are the same as after exposure to nitrogen - avoid mechanical damage and water ingress.
The next way to remove warts is electrocoagulation. In this case, a high frequency current is applied to the wart. The treatment is carried out under local anesthesia. Exposing a wart to high temperatures leads to the evaporation of cells affected by the papilloma virus. Another advantage of this method is that cauterization of the blood vessels prevents bleeding. After surgery, a scab forms on the affected area of skin, which disappears within 7 to 10 days.
A plantar wart can be treated with direct surgery. In this case, excision takes place under local anesthesia and then sutures are applied. After the operation, the doctor will prescribe some recommendations. Therefore, it is recommended to avoid getting soap and water on the affected area, not to pick off the resulting crust and to treat the affected area with an antiseptic for the first 7 to 10 days.
For each type of operation there are certain contraindications. Therefore, it will be impossible to carry out the operation if the following occurs:
- pregnancy;
- diabetes;
- malignant tumors in the body;
- infection and inflammation around the wart;
- exacerbation of herpes;
- elevated temperature.
If your blood pressure is high, the procedure should also be postponed.
Wart treatment without surgery
People often wonder how to remove a plantar wart without surgery. To do this, you can use pharmaceutical ointments and solutions.
Basically, these ointments have the following effects:
- anti-inflammatory;
- antiseptic;
- immunomodulator;
- antiviral;
- antifungal.
In addition, it may contain vitamin E, which also has a positive effect on treatment, as vitamins generally strengthen the body and reduce the risk of relapse.
It is important that these products are used for single, superficial plantar warts. Furthermore, if any side effects occur, it is necessary to wash the medicine with plenty of warm water and seek medical attention immediately.
So, it is possible to cure warts, there are many ways to do this, but you should not do it without first consulting a doctor, so as not to harm your health. Furthermore, self-medication is strictly prohibited if the attending physician prescribes contraindications.
Treatment of papillomas on the body
Hardware Methods
Modern hardware methods for treating papillomas make it possible to eliminate them and prevent the development of relapses of the disease. The most commonly used methods are:
- Cryodestruction is the destruction of growths by exposing them to low temperatures.
- Electrocoagulation is the cauterization of formations with electric current, the intensity and frequency of which are selected depending on the size, type and density of the papilloma.
- Laser removal. The type of impact is clear from the name. The procedure takes no more than 15 minutes and helps to eliminate unsightly growths forever.
Drug treatment
Among the medicines used are celandine, castor oil, pencil pencil, Sani Skin and Dermavit preparations.
They demonstrate variable effectiveness and do not prevent disease relapse. The main disadvantage of drug therapy for papillomas is the frequent development of allergic reactions.
Papilloma prevention
To prevent the appearance of growths and avoid infection with human papillomavirus, you must:
- Use barrier contraception during sexual intercourse.
- Observe personal hygiene rules and only use individual towels, soap and a toothbrush.
- When visiting public baths, don't forget to wear rubber shoes.
You should also normalize your daily routine, eat a balanced diet, abandon bad habits and avoid stressful situations. These factors are not the cause of the disease, but they can provoke its development if the virus is already present in the body.